Pancreatic Cancer Is Lethal Malignancy With A Mortality Rate

Pancreatic cancer is lethal malignancy with a mortality rate that almost equals its incidence. It is the 4th leading cause of cancer-related deaths in the United States, with only a 5-year survival rate of about 6%. Pancreatic cancer remains to be one of the most aggressive tumors. When diagnosed 60-80% patients already have locally advanced or the tumor has already metastasized. A majority of pancreatic cancers are derived from the exocrine part of the pancreas. The exocrine part of the pancreas produces digestive enzymes that help break down proteins, fats, and starches. There are several mutations that have been identified in pancreatic cancer; these mutations can lead to potential biomarkers, leading towards a better prognosis for high risk patients. A majority of exocrine pancreatic cancer patients exhibit a mutation in the proto-oncogene K-RAS (A.M. Lowy et al. 2008) and mutations in gene p16. K-RAS is a member of the RAS family of GTP-binding proteins; they’re essential in the role of cell proliferation, differentiation, and survival (Campbell et al. 1998; Malumbres and Barbacid 2003). Several studies have been able to identify the point mutation in K-RAS that are almost exclusively seen in pancreatic cancer. Point mutations at codon 12 (from CGT to GAT or GTT,) result in substitution of glycine with aspartate, valine, or arginine leading to an overactive K-RAS pathway. Once activated, K-RAS recruits and activates necessary proteins for the production of growthShow MoreRelatedVitamin C And Its Effect On Human Body9946 Words   |  40 Pagesalso resulted in iron absorption and hemoglobin levels in blood thus adversely affecting the oxygen carrying capacity of red blood cells. The reduced rate of riboflavin in pregnant women can induce multiple developmental deformities in the fetus. Some studies also report different adverse effects of deficiency of Riboflavin in different cancers. 1.2.3. Vitamin B3 or Niacin Niacin is a general term used for all the compounds which resemble the activity of vitamin B3. Vitamin B3 contain

Unit Learning and Professional Development - 843 Words

Unit 2 Merila 1.1 explain the importance of continually improving knowledge and practice Reflective practice is inoperative in order to ensure that high standards are kept continuously as circumstances children and environments change In order to reflect one must continuously be aware of approaches used and how they can be changed or developed to improve Continually improving and adapting approaches benefits both children and practitioners ensuring that each individual child needs are catered for Reflective practice involves evolving in a child centred approach The child carer benefits as his/her skills grow and develop ,enabling the highest standards of care and provision It also promotes a better level of understanding and†¦show more content†¦Reflecting on my own practice is important because it allows us to assess what I am doing well and identify areas where I might like need more training or guidance This will help to ensure that performing to the best meeting all necessary standards and expectations within our nursery’s policies and procedures It helps individuals to think about what they are doing and to always be aware of how they work with the children, families and team members. By Reflecting on our practice we can enhance and improve our confidence and self esteem because you can look at what you are doing well, the things we have learnt and achieved. This can make us feel good about ourselves, this can then give us the confidence to continue working well and to aim to try new things and to use what new skills or knowledge we have gained within our practice. In order to reflect on our practice we must be able to look at why and how we do things and to consider if a different approach may be beneficial. In order to be able to effectively reflect on our practice we must be able to be open- minded and question our own practice. If we can do this then it will help us to improve our own knowledge and skills. In order to develop these skills we should be able to: * Listen openly to the ideas of others * Reflect on your own work and the work of you team members * Consider ways to improve your practice and implement them. As a manager I encourage all the staff to take partShow MoreRelatedDepartment of Care and Professional Studies Edexcel Level 3 for Children and Young People’s Workforce Unit 13 Promoting Children’s Learning and Development in the Early Years Assignment Task 1 Direct Observation598 Words   |  3 PagesDepartment of Care and Professional Studies Edexcel Level 3 for Children and Young People’s Workforce Unit 13 Promoting Children’s Learning and Development in the Early Years Assignment Task 1 Direct Observation and Professional discussion Assessment Criteria (Unit 13) 1.3 explain how the documented outcomes are assessed and recorded 2.2 engage effectively with children to encourage the child’s participation and involvement in planning their own learning and development activities. 3.2Read MorePERSONAL ND PROFESSIONAL DEVELOPMENT Essays1351 Words   |  6 Pagesï » ¿ Lesson Plan – 2 PERSONAL AND PROFESSIONAL DEVELOPMENT Unit Title: Personal and Professional Development Topic: Personal Swot Analysis Week 2 Time: Variable Duration: 5 Hours Lecturers: Module Leader: Joy Meme Venue: Variable No of students: Variable Lesson Objectives: 1.Understanding of the use and concept of a Personal SWOT Analysis 2.Completion of a Personal SWOT Analysis 3.Reading and discussion of the article-â€Å"How to LeadRead MoreCipd Essay762 Words   |  4 PagesActivity Template Title of unit/s Developing Yourself as an Effective Learning Development Practitioner Unit No/s 4DEP (LD) Level Foundation Credit value 4 Assessment method Written, Discussion Learning outcomes: 1. Understand the knowledge, skills and behaviours required to be an effective LD practitioner. 2. Know how to deliver timely and effective LD services to meet users’ needs. 3. Be able to reflect on own practice and development needs and maintain a plan for personal Read MoreThe Impact Of District Level Leadership And Student Achievement1493 Words   |  6 Pagesmaximum potential. This is accomplished by being true to my core values of honesty, integrity, persistence and loyalty and providing those I lead with clarity of vision (direction and accountability), the opportunity and support needed for personal development (growth, responsibility and autonomy) and compassion for their struggle (understanding and patience). These beliefs manifest in my beliefs regarding educational leadership. The purpose of education is to provide avenues to bring students to theirRead MoreUnit 2 –Principles of Personal Development in Adult Social Care Settings.1473 Words   |  6 PagesLEVEL 2 – CERTIFICATE IN PREPARING TO WORK IN ADULT SOCIAL CARE UNIT 2 –Principles of personal development in adult social care settings. OUTCOME 1 Understand what is required for good practice in adult social care roles. 1.1 Identify standards that influence the way adult social care job roles are carried out. Below is a list of some of the legislations that are relevant to adult social care. These make up ‘standards’ to follow for good practice. * Care Standards Act 2000 Read MoreHealth Social Care Essay1172 Words   |  5 PagesBTEC NATIONAL Subsidiary Diploma Level 3 in Health and Social care UNIT 48 Exploring Personal and Professional Development in Health and Social Care. Teacher Name: Ms C Jumpp-Graham Guided Learning Hours: 60 hours Assessment Type: Internal 2012-2013 UNIT 48 ASSIGNMENT – Exploring Personal and Professional Development in Health and Social Care. IntroductionThis assignment is made up of a number of tasks which, when successfully completed, are designed to give you sufficientRead MoreDesigning A Stronger Behavior Management System1633 Words   |  7 PagesSelf-Assessment Creating and implementing this unit on division for this diverse fifth grade class was able to help me grow as an educator. While there were many strengths from this unit, there was also some areas of growth that could have been made in order to make the unit even more successful. One major strength from this unit was the differentiation of instruction and assessments. 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Lady Macbeth Is Responsible for the Fall of Macbeth Free Essays

Lady Macbeth is responsible for the fall of her husband It can be said that Lady Macbeth is responsible for the fall of Macbeth. I believe that she was partly responsible for this. I believe that two sets of people are responsible for the fall of Macbeth. We will write a custom essay sample on Lady Macbeth Is Responsible for the Fall of Macbeth or any similar topic only for you Order Now . Secondly I believe that Lady Macbeth is responsible for his fall. She urges him to kill Duncan questioning his manly-hood and saying that he was too kind. Finally I believe that the witches played a huge part in the fall of Macbeth. The witches put the thought of being king into Macbeth’s head in the first place. They also convinced him that he was invincible and this caused his ultimate death. I believe that Lady Macbeth is partly responsible for the fall of Macbeth. She plans and forces Macbeth to murder starting the chain reaction to his downfall. When Lady Macbeth read the letter that Macbeth sent her about his encounter with the witches she immediately starts planning Duncan’s murder. â€Å"The raven himself is hoarse That croaks the fatal entrance of Duncan Under my battlements† Lady Macbeth plans the whole murder and if Duncan had not looked like her father she would have done it herself. Had he not resembled My father as he slept, I had done’t† She forces Macbeth to carry out the murder even though he expresses that he doesnt want to do it. â€Å"We will proceed no further in this business:† â€Å"I have no spur to prick the sides of my intent, but only vaulting ambition ,which o’erlaps itself And falls on the other† Lady Macbeth accuses Macbeth of not loving her and questions his manly-hood in order to manipulate him into murdering Duncan. â€Å"When you durst do it then you were a man, And to be a more to be that what you were, you would e so much more the man† Lady Macbeth uses Macbeth’s lack of confidence to win him over and force him to finish the murder. â€Å"Art thou afeard To be the same in thine own act and valour As thou art in desire? † She thinks he is too â€Å"full of the milk of kindness† to fulfil the deed. This forced Lady Macbeth to convince him and manipulate him into killing Duncan. We see Lady Macbeth transform throughout the play. At the start of the play she may have been the catalyst to Macbeth rise and fall from power but by the end of the play she didn’t feature. She lost control of her mind from the guilt was suffering. Once Macbeth was king the relationship between the two disintegrated and they no longer confided in one another. Macbeth showed his true colours when he ordered for all the Macduff family to be killed, children and all. Lady Macbeth had nothing to do with this and therefore cannot be blamed entirely for Macbeth’s fall and ultimate death. Secondly, I believe that Macbeth was in some ways responsible for his own downfall. He was ambitious and strived to be the king. Once he became King he strived to stay King and became very suspicious and paranoid of all people in his country. Finally, the witches are partly responsible for Macbeth’s downfall. They meet Macbeth and Banquo on the way home from battle and they meet three witches. The witches tell Macbeth that he will become Thane of Cawdor and eventually King of Scotland. â€Å"All hail Macbeth! Hail to thee Thane of Glamis† â€Å"All Hail Macbeth! Hail to thee Thane of Cawdor† â€Å"All Hail Macbeth! Thou shalt be king hereafter.! † At first Macbeth doesn’t believe them but when he becomes Thane of Cawdor things start to make sense to him. After this he starts getting murderous thought and the fall of Macbeth begins. Macbeth is ambitious and his personality changes when he believes he can be king. He loses all his nobility and honour. â€Å"Glamis and Thane of Cawdor! The greatest is behind! † The witches also play another role in the fall and ultimate death of Macbeth. Macbeth goes to the witches a second time to find out his future. They tell him the future in the form of three apparitions. They tell him that he must beware of Macduff, he cannot be killed by man born of woman and he will die when the Great Birnam Woods come to Dunsinane. â€Å"Macbeth! Macbeth! Macbeth! beware Macduff; Beware the thane of Fife. † â€Å"Be bloody, bold, and resolute; laugh to scorn The power of man, for none of woman born Shall harm Macbeth. † â€Å"Be lion-melted, proud; and take no care Who chafes, who frets, or where conspirers are: Macbeth shall never vanquish’d be until Great Birnam wood to high Dunsinane hill Shall come against him. † He believes every word of the witches to be gospel and this cause his ultimate death. He is convinced that he cannot die that he is invincible. When Macduff confronts Macbeth he tells him of their prophecy. As a result of the prophecy Macbeth believes he is invincible and this allows Macduff and his troops to get very close to Macbeth and this causes his death at the end of the play. â€Å"I bear a charmed life, which must not yield To one born of woman† The witches manipulated Macbeth into thinking he could fulfil the prophecy and become King of Scotland How to cite Lady Macbeth Is Responsible for the Fall of Macbeth, Essay examples

Life

Life-Defining Moments Essay I remember the day my world as I knew it fell apart. It was my 19th birthday and my boyfriend of almost four years sent me a text ending our relationship. Images of our wedding we had planned to the day, of our small house on base while he finished his four years in the marines, and the mental picture of what our children would look like was flashed before my eyes and one by one went up in smoke. Through the next few months I muddled though school alone and finally made it to spring break. While home I was debating what I wanted to do with my life, I was in a major I didn’t like, and all together pretty miserable. That was until I decided to have lunch with one of my best friends from high school Brittany. It was an experience I would never forget and one that made my view of myself, and my small town world change. Back in high school Brittany was the popular girl, pretty, ambitious, fiercely independent, with a fashion sense that could blow Louis Vuitton out of the water. So when she announced she was going to attend the University of Central Missouri for their fashion program no one was surprised. Then about the time of graduation she met Jeff a small town sheriff deputy and they started dating but none of us saw it getting serious. I hadn’t seen or heard from her much since we left for college-mainly due to the fact that she thinks Facebook and twitter are an invasion of privacy-so I didn’t know what she was up to until we met in town at the restaurant we both use to work at. I was excited to hear how fashion school was and if Jeff and her were even still dating since Brittany normally went through boys like Kleenex, but what came out of her mouth sent me reeling. She had dropped out of fashion school in order to move in with Jeff out in the middle of the country, she was waitressing part time at a local place and they were planning on getting married in the summer and soon starting a family. As I sat in those familiar solid oak benches surrounded by the wafting aroma of cheese burgers I was staggering to understand this new reality. As I listened to her stunned she told tales of redecorating Jeff’s trailer, and how they had gotten a puppy together, I started to realize that two emotions were rapidly growing inside me. One was anger at her for throwing her life away for some hick country boy, and the other was a staggering overwhelming realization that we had just switched places. When I left high school I had a military boyfriend who wanted me to do the college thing for a semester and then come out to live with him, get married, and quickly start a family, and at the time that was also what I wanted. Then after a semester as I thought of what was to come over Christmas break I couldn’t explain it but married life a part time job and children just wasn’t appealing to me anymore, in fact it kind of completely terrified me. So when I finally said I was staying at college he broke it off stating he couldn’t date someone who would make more money or have a higher degree of education then him. Now sitting across the table was my best friend who was exactly where I was supposed to be at this time making a home and a small town life for herself, and I wanted no part in it, I actually was angry about what she was doing with her life. I left our lunch in a state of confusion and a cloud of mixed emotions, all my life I had been surrounded by couples that were high school sweethearts, heck most girls from my graduating class were married, engaged, or pregnant already, and thinking of that as my life made me sick. I wanted a high paying job, a position of power in a company, I wanted to travel and live in a big city, and I didn’t want a husband and kids anytime soon. When I came home and people started to hear the news that I was pursuing a degree and not a relationship my home townsmen shunned the ideal, and me. Hurricane flloyd EssayThis caused me to question so many choices in my life, it made me look back on all the times I had purposely put myself in second place because I thought it was a man’s world. So when I started to reflect on my major which at the time was architecture I realized that I had compromised yet again. I had started senior year wanting to do architectural engineering and was told it was to math and science heavy for a girl and that architecture was more design based and therefore more suited for a women’s talents. I still wasn’t happy with this explanation so I continued to look into architectural engineering, and found a surprising fact. In most colleges and in the professional world men outweighed women by about 30 to 1! A lot of people refer to engineering as a 50 hour career, meaning if you choose to specialize in this forget your 9-5 work week. You’re going to be in the office some morning very early to very late at night, and working on weekends sometimes is a must. This in the past has deterred women from entering this field because of the strain this time commitment puts on those with families. Even if women do want to make this time commitment society questions them, they put pressure on them to have families and a job that allows them to be home to cook dinner, and sometimes in engineering it’s just not possible. Also with engineering it is very math and science based, these are seen as things that boys are good at where as women are design and color oriented, and this fact yet again deters women from entering the field. So into architecture I went because I was told that where I would fit in, and I very soon realized that I hated it! Every girl around me could come up with amazing design ideas and color concepts and I just couldn’t. I found myself missing math and the challenge it presented, yet when I spoke with an advisor she told me the same thing I’d been hearing since graduation â€Å"that’s really more of a difficult major then most females can handle†. And if you look at Kansas states engineering school you’d think that was true, there are about 12 men to every 1 women. So I took that as my university saying they’d would rather have men in the program then someone like me. I knew I wasn’t happy in architecture but I wasn’t sure if I could make it in a man’s world. I wasn’t a math whiz, and science wasn’t my best subject. Everything from my past was running through my head making me question my role of being a women. Should I go with the traditional values that had been placed on me, or should I go with what I think was right for me. After much consideration I decided that gender role or not I wasn’t going to be happy unless I switched. So after finals I went home for summer break and had a long discussion with my parents. I told them about my math worries and how I didn’t want to be the only girl, but they supported me as I called my advisor and made the change. Thus far I must say it’s been the best decision I could have ever made. I came to see I liked math and I’m good at it, and I missed looking at the structure and how things worked verses just making them pretty. I plan on going into a large firm and working up until I can one day own my own architectural engineering firm in a larger city like Chicago or Dallas. So here I am defying everything I’ve grown up believing, single, and in a major that has 30+ males to every female and I couldn’t be happier with how my life is turning out.